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Excelsior riders fuel triple negative breast cancer research

Each year, Excelsior riders who raised $20,000 or more fund one unique project approved by the Scientific Advisory Committee (SAC) for its high potential. Here’s a look at the most recent SAC grant designation. 

Fueling Triple Negative Breast Cancer Research

Education Site - Dr. Azrak OICO Program 2.4.21-41
Dr. Mukherjee Lab Photos November 8, 2022-27 (4)

At Roswell Park, our researchers are constantly asking the next question and working toward new discoveries. Many times, those groundbreaking findings begin with a simple question or a small data set. Major national funding for cancer research doesn’t come into play until a scientist can prove they have a solid foundation and are already well on their way to something big.

Our solution is the Scientific Advisory Committee (SAC). Roswell Park researchers submit unique project proposals to understand something deeper about their dedicated cancer focus. Through a competitive and rigorous process, the projects with the highest potential and most established groundwork are selected for funding.

These SAC grants are made possible by the generosity of road warriors and their donors, without whom, many of these projects could not get off the ground and make their marks on cancer as we know it. For every $1 donated to the Roswell Park Alliance Foundation and invested into research initiatives, researchers go on to earn an additional $23 in external grant funding, further fueling their lifesaving work. In other words, after donor funding has allowed their work to flourish, they’re empowered to seek and win larger grants to make an even bigger impact and follow the thread of innovation they’re chasing.

“But the true magnitude of that impact is much greater than the $23,” said Mukund Seshadri, DDS, PhD, Co-Chair of the Scientific Advisory Committee, Associate Director of Cancer Research Training and Education Coordination and Chair of the Department of Oral Oncology. “It has allowed people to pursue ideas, it has allowed us to develop and move things forward. Maybe therapies that would have still been in the lab somewhere are actually now in clinical trials that we’re running at Roswell Park. An approach to mitigate toxicity in a cancer patient might not have been pursued at all if not for this funding.”

It has allowed people to pursue ideas, it has allowed us to develop and move things forward. Maybe therapies that would have still been in the lab somewhere are actually now in clinical trials that we're running at Roswell Park. An approach to mitigate toxicity in a cancer patient might not have been pursued at all if not for this funding.”

The following research initiative was specifically funded by the generosity of the 2022 Empire State Ride Excelsior riders who raised $20,000 or more and those who donated to their fundraising efforts.

Immuno-Metabolic Regulation in Triple Negative Breast Cancer

Subhamoy Dasgupta, PhD, and Scott Abrams, PhD

Breast cancer detection and treatment continues to improve, but in too many cases for patients with triple negative breast cancer, the cancer returns in an aggressive, metastatic form where therapeutic options are severely limited. The cancer cells in these situations have developed strategies to adapt and evade the immune system, enabling them to become more aggressive.

One way the cancer grows is by increasing a specific metabolic enzyme that can act as a driver of this variant. When there is more of this enzyme, there is poorer survival. In contrast, metastasis to the lungs and lymph nodes are significantly less when the enzyme is reduced.

Drs. Dasgupta and Abrams, along with their team, hope to uncover the intricacies of how this enzyme drives the growth of triple negative breast cancer by suppressing immunity so we can ultimately learn how to stop it with new therapeutic combinations.

Top fundraisers bring innovative research to the forefront

2021 Top Fundraisers Brought an Innovative New Research Project to Roswell Park

Every year, Empire State Ride brings in funds that are dedicated toward Roswell Park’s mission to continue to uncover better ways to prevent, diagnose and treat all kinds of cancers. Road warriors pave the way for lifechanging new treatments, groundbreaking clinical trials and innovative research and discoveries.

On Sac Grants

Roswell Park is pushing to eliminate cancer’s grip on humanity every day. Over the years, we’ve seen the genesis of groundbreaking and lifesaving advances right here in Buffalo. Those new treatments and findings all have their start with new questions and ideas from Roswell Park scientists.

 

That’s where Roswell Park’s Scientific Advisory Committee (SAC) comes in. Researchers submit their project proposals, all looking to continue to learn more about cancer. Through a competitive and rigorous process, these investigators and their work have been funded. These grants are made possible by the generosity of Roswell Park fundraisers and their donors, without whom, these projects could not get off the ground and make their marks on cancer as we know it.

From Fundraising to research

In 2022, the funds raised by the 2021 top Excelsior fundraisers (those who raised $20,000 or more) for Empire State Ride were put toward one project in particular. These road warriors have empowered Roswell Park to investigate racial health disparities for African American men with prostate cancer in a project led by Anna Woloszynska, PhD, Roswell Park Associate Professor of Oncology in the Department of Pharmacology & Therapeutics.

 

In Western New York, African American men are more likely than other men to have prostate cancer, more likely to have aggressive forms and more likely to lose their battle. Dr. Woloszynska’s research will take a deeper look at these patients’ epigenetic age — a way of determining age not in terms of one’s chronological age or time on Earth, but their biological age, taking into account disease risks and exposures — to determine if their epigenetic age is accelerated and if that contributes to early onset disease in patients younger than 55 years old. The findings will lay the groundwork for discoveries that will hopefully identify higher risk individuals and save more lives, reducing and ultimately eliminating the existing racial health disparity.

Top 2021 Excelsior Fundraisers

This work is made possible by the top ESR 2021 Excelsior fundraisers and their donors:

·         John Arfman

·         Terry Bourgeois

·         David Brown

·         Thomas Flynn

·         Anne Gioia

·         Gary Kuhlmann

·         Jerry Lewandowski

·         Richard Noll

·         Maria Coccia Thor

·         Geoffrey Wilk

 

Because of these riders and everyone who supported them, Roswell Park will be able to gain a deeper understanding of cancer and seek to bridge gaps in healthcare, providing the best possible treatment for every patient. Thanks to road warriors and every person who contributes to Empire State Ride, research like this can continue to move forward, guiding us in the best ways to fight cancer.

Looking forward

In the same way, the 2022 top fundraisers are going to make a direct impact on emerging cancer research at Roswell Park. Keep an eye out for those fundraisers and the work their fundraising will support.

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